The F50 used a 4.7L naturally aspirated V12 developed from the 3.5L V12 that was used in the 1990 Ferrari 641 Formula 1 car. Before being used in the F50, this engine was in the Ferrari 333 SP racing in the American IMSA series for 1994.
The chassis was a carbon fiber tub with the engine and transmission unit providing structural support for the car removing the need for a sub frame. This meant the rear suspension was connected directly to the engine and gearbox unit like a Formula 1 car.